Nicolas Roy scored twice, snapping a 17-game goalless drought.
The Golden Knights are coming off back-to-back road losses (0-1-1).
The Golden Knights have recalled forward Sheldon Rempal from Henderson.
The Golden Knights outshot the Ducks 51-27.
Vegas will look to improve on its 14-3-1 road record this season.
Vegas gave up three unanswered goals in a game that featured just 48 shots.
The Golden Knights have a 14-9-3 all-time record against Los Angeles.
The trio combined for nine points and two shootout goals in the win.
Vegas can finish the four-game homestand 2-2-0 with a win tonight.
Vegas scored four times in the third period for its first home win since Dec. 9.
Vegas has lost three straight home games and six of its last seven.
Reilly Smith scored his league-leading fourth shorthanded goal of the year.
The Golden Knights won the first two meetings and are 5-6-2 all-time.
Jack Eichel was placed on injured reserve and will miss at least two games.